When it comes to sex, there's "incompatibility" and there's incompatibility. "Don't thrust so fast." "Why don't you ever squeeze my nuts while we do it?" "I orgasm harder when I'm on top." -- all live in the world of "incompatibility." As you rightfully point out, issues like those just mentioned can be modified and adjusted.
But then every once in a while you'll find couples with plenty of love paddling hopelessly up sh*tty-sex creek. These couples are battling things like fitting a watermelon (penis) into a teacup (vagina); or a pinky (penis) into a refrigerator (vagina); or painfully incongruent body smells or diametrically opposed approaches to intercourse.
I know you're a virgin, but I don't know if you are asking this because of your impending sex with a specifc boyfriend or not. Perhaps your question is pure theory and curiosity. If not I would use the information you already have about your man from his crotch to his brain and estimate for yourself if things may shake out well.
Funny Guy
If the issue is small as Funny Guy point out, you can work around it.
Simple likes and dislikes can be taught to your partner and worked through. But if the incompatibility is large, it cannot always be worked around. Like, I don't like having my nipples played with but most men think it is a go to move to arouse a girl. If you tell them enough and show them what you like, it can be worked through.
Larger things that cannot be worked through are usually deal breakers as most romantic relationships are not sustainable without sex. Like a man who only likes anal with a girl who will not do it - that is an incompatibility that cannot be worked through no matter how much the people try to learn to please each other.